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Cell Line Name：

Host Cell:

Ba/F3

Freeze Medium:

Complete Culture Medium:

Mycoplasma Status:

Negative

PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035).

1.Sanger of PDGFRA V658A-V561A/BaF3

Figure 1. PDGFRA V658A-V561A/BaF3 V658A

Figure 2. PDGFRA V658A-V561A/BaF3 V561A

2. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BaF3 PDGFRA V658A Cells (C3).