| 名稱(chēng) | CTNNB1 p.S37F Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10253 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CTNNB1 p.S37F Reference Standard |
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10253CTNNB1 p.S37F Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
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CBP10253 | |
| Format | Genomic DNA |
| Description | CTNNB1 S37F lies within the ubiquitination recognition motif of the Ctnnb1 protein and occurs at a Gsk3b phosphorylation site on the Ctnnb1 protein (PMID: 10347231). S37F is predicted to confer a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1 (PMID: 11196159, PMID: 11943721) and increased cell invasion and migration in the context of an EGFR activating mutation (PMID: 29106415). |
| Technical Data | |
| DNA Change | c.110C>T |
| AA Change | p.S37F |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000349496 |
| Cosmic ID | COSM5662 |
| Chr position(GRCh37) | chr3:41266113 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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