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C-C chemokine receptor type 1 (CCR8) is a G protein-coupled receptor member of the CC chemokine subfamily of
receptors. Following interaction with its specific chemokine ligands, like macrophage inflammatory protein 1 alpha
(MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), and monocyte
chemoattractant protein 3 (MCP-3), it triggers the onset of a process known as chemotaxis. GenScript’s human
CCR8-expressing stable subline is guaranteed to function properly in the calcium flux assay.

CHO

Functional assay for CCR8 receptor

Figure 1. Dose response of Human Recombinant CCL1 in CCR8 β-Arrestin/CHO-K1 Cell Line (C6).

Figure 2. Inhibition of CCL1-induced Beta-Arrestin Recruitment By CCR8 Blocking Ab in CCR8 Beta-Arrestin CHO-K1 Cells.